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Departmental Seminar: Md. Altaf-Ul-Amin

Tuesday, 21st March 2017 1:00 pm
Where: EITC E2-105

Title: Structural Similarity based Multifaceted Analysis of Metabolites using KNApSAcK Database and DPClus Algorithm


Initially, we developed KNApSAcK as a species-metabolite relational database and subsequently, inspired by its popularity we extended it to KNApSAcK family databases by adding different types of omics data together with data regarding edible plants and traditional medicines mainly focusing human health care and ecology. Previously we also developed graph clustering algorithms DPClus and DPClusO, which we and many other researchers applied to analysis of versatile omics data. In the present talk, first, I will briefly focus on the KNApSAcK database and the DPClus algorithm. Then I will discuss two of our recent publications. One is on development and mining of a volatile organic compound (VOC) database. VOCs play important roles in chemical ecology specifically in the biological interactions between organisms and ecosystems. VOCs are also important in the health care field as they are presently used as biomarkers to detect various human diseases. The other topic of my talk is a network-based approach to analyze relationships between 3D structure and biological activity of metabolites. By applying our method to a data set consisting of 2072 secondary metabolites and 140 biological activities reported in KNApSAcK Metabolite Activity DB, we have obtained 983 statistically significant structure group-biological activity pairs which implies relations between chemical structures and biological activities of metabolites.
Md. Altaf-Ul- Amin received B.Sc. degree in Electrical and Electronic Engineering from Bangladesh University of Engineering and Technology (BUET), Dhaka, M.Sc. degree in Electrical, Electronic and Systems Engineering from Universiti Kebangsaan Malaysia (UKM) and PhD degree from Nara Institute of Science and Technology (NAIST), Japan. He received the best student paper award in the IEEE 10 th Asian Test Symposium. Also, he received two other best paper awards as a co-author of journal articles. He previously worked in several universities in Bangladesh, Malaysia and Japan. Currently he is working as an associate professor in Computational Systems Biology Lab of NAIST. He is conducting research on Network Biology, Systems Biology, Cheminformatics and Biological Databases. He published around 60 peer reviewed papers in international journals and conference proceedings.
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